A micromechanical model for the growth of collagenous tissues under mechanics-mediated collagen deposition and degradation
In this study, we developed a micromechanical model for the growth and remodeling of a soft tissue based on the concurrent action of collagen deposition and degradation. We assumed in the model that collagen degradation causes a reduction in the fiber radius, while collagen deposition can increase both the radius and length of the collagen fibers growing under load. The latter arises from the assumption that collagen is deposited in an unstressed state, which increases the reference length of a fiber growing under mechanical load.