Critical role of cytoskeletal prestress in cellular stiffening
In his recent comment, Isabey discussed the issue of external stress/strain induced cellular stiffening. While the mechanism of this behavior is not fully understood and deserves further investigation, I would like to mention the cellular stiffening (increase of shear stiffness) that depends on the level of the endogenous contractile prestress (pre-tension) generated by myosin II-actin interactions.