In this paper we present a methodology for reverse engineering of trabecular bone like architectures using multi-objective topology optimization. We then investigate the mechanical properties of the resulting network structures. Specifically, we show that structures optimized according to Wolff's law alone may be stiffest but they are also fragile.
Draft accessible here: https://www.researchgate.net/publication/334558304_Characterization_of_fracture_in_topology-optimized_bio-inspired_networks