I am happy to announce the publication of a book "Simulations in Nanobiotechnology", which was contributed from researchers (including iMechanicians) who have expertise in the area of nanobiotechnology. The book is aimed at presenting the current state-of-arts in computational simulations of biological objects such as proteins as well as nanomaterials such as graphene, and also bio-nano-hybrid system such as nanopore-biomolecule interactions. This book provides the insight into the simulation-based characterization in nanobiotechnology.

Nanomechanical Actuation Driven by Light-Induced DNA Fuel

Kilho Eom, Huihun Jung, Gyudo Lee, Jinsung Park, Kihwan Nam, Sang Woo Lee, Dae Sung Yoon, Jaemoon Yang, and Taeyun Kwon

Abstract

We have recently suggested the potential of resonant microcantilever for quantitative study on the kinetics of biomolecular interactions such as protein-protein interaction and DNA hybridization. We have employed the Langmuir kinetic model for describing the molecular interactions on the surface, which leads to change of overall mass of cantilever responsible for resonant frequency shift. Such Langmuir kinetic model dictates the in situ resonant frequency shift due to biomolecular interaction in liquid. This indicates that resonant cantilever is able to provide the information of biochemical reaction. This work was published in Applied Physics Letters in Oct 31, 2008.

Resonance frequency of a cantilever beam is given by

f=(kn/2pi)*sqrt(EI/mL4)

where, kn=3.52 for cantilever, E is Young's Modulus, I is moment of Inertia, m is mass, L is beam length.

The equation is available in Raymond J. Roark and Warren C. Young, “Formulas for Stress and Strain”, McGraw-Hill, Kogakusha, 5th Edition, (1976).

resonance (natural) frequency of a cantilever beam is given by

f=[kn/2pi][sqrt(EI/wL^4)] where, kn=3.52 for mode 1, E is Young's modulus, I is moment of Inertia, w is beam width, L is beam length. (this is from Formulas for Stress and Strain, 5th edition by Raymond J. Roark and Warren C. Young).

 I would like to derive this formula. Can any one suugest me any book or any link?  

We have recently reported the label-free detection of HCV (Hepatitis C Virus) helicase by using a resonating microcantilever whose surface is functionalized by RNA aptamers as receptor molecules. This work was accepted for publication at Biosensors & Bioelectronics.

Abstract

We have recently reported the piezoelectric thick film microcantilever, which enables the in-situ real-time detection of the protein related to disease (e.g. C reactive protein) in liquid environment. This work was published at APL (click here).

"In-situ real-time monitoring of biomolecular interactions based on resonating microcantilevers immersed in a viscous fluid"

We recently reported the mass sensing by using resonating microcantilevers. The characterization of mass-sensing and its related sensitivity was suggested on the basis of elasticity theory. This work was published online at Sensors and Actuators A (click here).

Microcantilevers have taken much attention as devices for label-free detection of molecules and/or their conformations in solutions and air. Recently, microcantilevers have allowed the nanomechanical mass detection of thin film [1-3], small molecules [4, 5], and biological components such as viruses [6] and vesicles [7] in the order of a pico-gram to a zepto-gram. The great potential of microcantilevers is the sensitive, reliable, fast label-free detection of proteins and/or protein conformations. Specifically, microcantilevers are capable of label-free detection of marker proteins related to diseases, even at a low concentration in solution [8-17]. Microcantilevers, operated in a viscous fluid, have also enabled the real-time monitoring of protein-protein interactions [8, 12-15]. Furthermore, microcantilevers are able to recognize the specific protein conformations [18] and/or reversible conformation changes of proteins/polymers [19, 20].